Privileged substructures for anti-sickling activity via cheminformatic analysis
نویسندگان
چکیده
منابع مشابه
An in vitro study on anti-sickling activity of Terminalia arjuna and Terminalia bellirica
Background & Aim:Combretaceae family is known for efficacy in the management of sickle cell disorder (SCD). Based on the earlier reports of anti-sickling property of Terminalia genus the study investigates in vitro antisickling properties of Terminalia arjuna and Terminalia bellirica. Experimental: Anti-sickling ...
متن کاملAn in vitro study on anti-sickling activity of Terminalia arjuna and Terminalia bellirica
Background & Aim:Combretaceae family is known for efficacy in the management of sickle cell disorder (SCD). Based on the earlier reports of anti-sickling property of Terminalia genus the study investigates in vitro antisickling properties of Terminalia arjuna and Terminalia bellirica. Experimental: Anti-sickling ...
متن کاملComparative evaluation of fifteen anti-sickling agents.
Fifteen compounds reported to be inhibitors of gelation or sickling were studied by standard methods. These tests included (1) the determination of the solubility of deoxyhemoglobin S or Csat, (2) evaluation of sickling in whole SS blood at various pO2s, (3) measurement of the oxygen affinity of hemoglobin and blood, and (4) examination of red cell indices and morphology. Among the 4 noncovalen...
متن کاملChemical substructures that enrich for biological activity
MOTIVATION Certain chemical substructures are present in many drugs. This has led to the claim of 'privileged' substructures which are predisposed to bioactivity. Because bias in screening library construction could explain this phenomenon, the existence of privilege has been controversial. RESULTS Using diverse phenotypic assays, we defined bioactivity for multiple compound libraries. Many s...
متن کاملan in vitro study on anti-sickling activity of terminalia arjuna and terminalia bellirica
background & aim:combretaceae family is known for efficacy in the management of sickle cell disorder (scd). based on the earlier reports of anti-sickling property of terminalia genus the study investigates in vitro antisickling properties of terminalia arjuna and terminalia bellirica. experimental: anti-sickling assay of methanolic and aqueous extract of t. arjuna and t. bellirica on ...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2018
ISSN: 2046-2069
DOI: 10.1039/c7ra12079f